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KMID : 0043319950180040289
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Archives of Pharmacal Research
1995 Volume.18 No. 4 p.289 ~ p.292
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Anti-hepatotoxic Activity of Icariside II, a Constituent of Epimedium koreanum
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Cho Nam-Jin
Sung Sang-Hyun
Lee Heum-Sook
Jeon Mee-Hee
Kim Young-Choong
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Abstract
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Icariside II, a flavonol glycoside, was isolated from the aerial part of Epimedium Koreanum Nakai by the anti-hepatotoxic acitivity guided fractionation technique employing primary cultured rat hepatocytes as an assay system. Its anti-hepatotoxic activity was evaluated by measuring activity of glutamic pyruvic transaminase released from the primary cultured rat hapatocytes. Icariside II significantly reduced the activity of glutamic pyruvic transaminase released from the primary cultured rat hepatocytes and resulted in 78% recovery of the toxicity at the concentration of . The anti-hepatotoxic activity of icariside II on the primary cultured rat hepatocytes was as potent as that of silybin.
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KEYWORD
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Anti-hepatotoxic activity, lcariside II, Epimedium koreanum, Glutamic py-ruvic transaminase, Primary cultured rat hepatocytes
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